2026 NDC/HCPCS Crosswalk

The NDC/HCPCS Crosswalk file provides a list of National Drug Codes (NDC) linked to Level II HCPCS codes, including pricing conversion factors for billable claims submitted to the DME MACs. This crosswalk enables the processing of claims using the NCPDP format. It includes prescription drugs administered in a home setting that are eligible for reimbursement under the DMEPOS benefit.

The PDAC updates the crosswalk monthly to add, revise, or delete NDCs as published in the RED BOOK drug compendium. The prepared NDC/HCPCS Crosswalk files below outline these updates and changes.

For NDC/HCPCS crosswalk questions, view our NDC/HCPCS Crosswalk FAQs and Definitions.