2026 NDC/HCPCS Crosswalk


The NDC/HCPCS Crosswalk file provides a list of National Drug Codes (NDC) linked to Level II HCPCS codes, including pricing conversion factors for billable claims submitted to the DME MACs. This crosswalk enables the processing of claims using the NCPDP format. It includes prescription drugs administered in a home setting that are eligible for reimbursement under the DMEPOS benefit.

The PDAC updates the crosswalk monthly to add, revise, or delete NDCs as published in the RED BOOK drug compendium. The prepared NDC/HCPCS Crosswalk files below outline these updates and changes.

For NDC/HCPCS crosswalk questions, view our NDC/HCPCS Crosswalk FAQs and Definitions.

 

September 2026

NDC to HCPCS Crosswalk (Excel, 1398 KB)
NDC to HCPCS Crosswalk (PDF, 2742 KB)
Date Changes (PDF, 126 KB)
Coding Changes (PDF, 72 KB)
Conversion Factor Changes (PDF, 77 KB)
Records and NDCs Added (PDF, 85 KB)
Records and NDCs Removed (PDF, 86 KB)
Additional Changes (PDF, 74 KB)

August 2026

NDC to HCPCS Crosswalk (Excel, 1140 KB)
NDC to HCPCS Crosswalk (PDF, 2745 KB)
Date Changes (PDF, 80 KB)
Coding Changes (PDF, 73 KB)
Conversion Factor Changes (PDF, 77 KB)
Records and NDCs Added (PDF, 95 KB)
Records and NDCs Removed (PDF, 83 KB)
Additional Changes (PDF, 74 KB)

July 2026

NDC to HCPCS Crosswalk (Excel, 1131 KB)
NDC to HCPCS Crosswalk (PDF, 2794 KB)
Date Changes (PDF, 106 KB)
Coding Changes (PDF, 71 KB)
Conversion Factor Changes (PDF, 76 KB)
Records and NDCs Added (PDF, 92 KB)
Records and NDCs Removed (PDF, 79 KB)
Additional Changes (PDF, 73 KB)

June 2026

NDC to HCPCS Crosswalk (Excel, 1131 KB)
NDC to HCPCS Crosswalk (PDF, 2794 KB)
Date Changes (PDF, 106 KB)
Coding Changes (PDF, 71 KB)
Conversion Factor Changes (PDF, 76 KB)
Records and NDCs Added (PDF, 92 KB)
Records and NDCs Removed (PDF, 79 KB)
Additional Changes (PDF, 73 KB)

May 2026

NDC to HCPCS Crosswalk (Excel, 1125 KB)
NDC to HCPCS Crosswalk (PDF, 2785 KB)
Date Changes (PDF, 75 KB)
Coding Changes (PDF, 71 KB)
Conversion Factor Changes (PDF, 76 KB)
Records and NDCs Added (PDF, 86 KB)
Records and NDCs Removed (PDF, 83 KB)
Additional Changes (PDF, 73 KB)

April 2026

NDC to HCPCS Crosswalk (Excel, 1380 KB)
NDC to HCPCS Crosswalk (PDF, 2785 KB)
Date Changes (PDF, 79 KB)
Coding Changes (PDF, 75 KB)
Conversion Factor Changes (PDF, 78 KB)
Records and NDCs Added (PDF, 98 KB)
Records and NDCs Removed (PDF, 101 KB)
Additional Changes (PDF, 75 KB)

March 2026

NDC to HCPCS Crosswalk (Excel, 1123 KB)
NDC to HCPCS Crosswalk (PDF, 2779 KB)
Date Changes (PDF, 82 KB)
Coding Changes (PDF, 75 KB)
Conversion Factor Changes (PDF, 79 KB)
Records and NDCs Added (PDF, 87 KB)
Records and NDCs Removed (PDF, 85 KB)
Additional Changes (PDF, 76 KB)

February 2026

NDC to HCPCS Crosswalk (Excel, 1122 KB)
NDC to HCPCS Crosswalk (PDF, 2775 KB)
Date Changes (PDF, 81 KB)
Coding Changes (PDF, 73 KB)
Conversion Factor Changes (PDF, 77 KB)
Records and NDCs Added (PDF, 93 KB)
Records and NDCs Removed (PDF, 83 KB)
Additional Changes (PDF, 75 KB)

January 2026

NDC to HCPCS Crosswalk (Excel, 1389 KB)
NDC to HCPCS Crosswalk (PDF, 2767 KB)
Date Changes (PDF, 82 KB)
Coding Changes (PDF, 80 KB)
Conversion Factor Changes (PDF, 78 KB)
Records and NDCs Added (PDF, 104 KB)
Records and NDCs Removed (PDF, 318 KB)
Additional Changes (PDF, 75 KB)

Last Updated: 08/31/2026